Liquichek Serum Indices Product Description

Pre-analytical Variation

Pre-analytical variation is a significant issue in laboratory medicine as laboratory-associated pre-analytical errors account for a large majority of all mistakes. Some regulatory agencies and laboratory medicine associations are emphasizing the importance of reducing pre-analytical errors and International Standard ISO 15189:2012 includes expanded pre-examination procedures. (1)

Specimen interferences are a contributor to pre-analytical variation that affects clinical chemistry testing. Most major chemistry platforms include automated spectrophotometric detection technology to measure the level of common interferences, Hemolysis, Icterus and Lipemia (HIL). These specimen interferences may be caused by disease, inappropriate fasting, sample processing, transportation, and storage. (1)

Advances in interference monitoring

Liquichek Serum Indices is designed to monitor an instrument’s ability to detect hemolyzed, icteric or lipemic (HIL) specimens to help improve detection of pre-analytical errors. Pre-analytical detection of HIL is an important laboratory procedure to increase confidence in patient test results.

Improve your laboratory’s efficiency and reduce pre-analytical errors

Increase your confidence in instrument performance by using Liquichek Serum Indices to help reduce your laboratory’s pre-analytical HIL interference testing errors. Liquichek Serum Indices can also be used as part of the pre-analytical phase of your Individualized Quality Control Plan (IQCP). Based on a US customer survey the majority of respondents would use Serum Indices daily or once a shift, depending on the laboratory’s volume of testing.

Monitors instrument responses in detecting common HIL specimen interferences

  • Based on absorbance measurements rather than subjective visual assessment
    (CLSI C56-A)

Important part of laboratory procedure

  • Helps provide greater confidence in reporting patient test results

Unity Interlaboratory data management program

  • Tracks instrument performance
  • Powerful peer group comparison
  • Easy-to-read reports

Regulators are taking note:
ISO 15189:2012 includes expanded pre-examination procedures, and the IFCC* is recommending standardized “Quality Indicators” in an effort to reduce the volume of pre-analytical errors. (1)

Liquichek Serum Indices is a product that monitors pre-analytical instrument detection of HIL specimen interferences. It is not intended for use in diagnosis, cure, mitigation, treatment, or prevention of disease.

(1) Mahboobe Ghaedi, PhD and Joe M. El-Khoury, PhD, “Pre-Analytical Variation,” Clinical Laboratory News (CLN) Vol 43, no. 7 (2016): 26-30.

* International Federation for Clinical Chemistry and Laboratory Medicine.

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