Liquichek Serum Indices HIL Monitoring

Instrument Response Monitoring for HIL Interferences

Recommendations for running Liquichek Serum Indices:

  • Treat this product the same as a patient specimen
  • Use Sodium as the trigger assay per level for Serum Index (HIL) measurement(1)
  • Run individual levels in the following order, HILN
  • Non-interfered level may be used last to flush the probe
  • Values include quantitative results and qualitative interpretations

Liquichek Serum Indices is not a stand-alone assay. Therefore, an inexpensive test method will need to be selected as the “trigger assay” to challenge the detection of the interferents within the automatic HIL detection module on the chemistry analyzer. Sodium is typically chosen because it is a commonly tested analyte and it is inexpensive to run. Sodium is not to be used for any daily QC determination.

Compatible with major chemistry instruments.

Liquichek Serum Indices is a product that monitors pre-analytical instrument detection of HIL specimen interferences. It is not intended for use in diagnosis, cure, mitigation, treatment, or prevention of disease.

Liquichek Serum Indices

Representative values are provided for HIL when testing is performed on the Siemens Dimension Vista® 500 using Sodium as the trigger assay per level for Serum Index (HIL) measurement. The actual observed values may vary depending upon lot number, analyzer or method.

Liquichek Serum Indices
Representative Results – Dimension Vista 500
Level H-Indices I-Indices L-Indices
Hemolysis 7 1 1
Icterus 1 7 1
Lipemia 1 1 8
Non-interfered 1 1 1

Report highlighted results only into Unity

Liquichek Serum Indices Index Results - Equivalency with CLSI 56-A

The following CLSI tables show the equivalent index ranges corresponding to Representative Results listed above. This table gives an approximate guide for results on other instruments.

CLSI 56-A: Serum Index Reference Tables

Hemolysis Index CLSI Hemolysis Appearance Scale Hemoglobin (mg/dL) Representative Indices Result
1 - H ≤ 10
2 + 10 < H ≤ 25
3 + 25 < H ≤ 50
4 ++ 50 < H ≤ 200
5 ++ or +++ 200 < H ≤ 300
6 +++ 300 < H ≤ 500
7 ++++ 500 < H ≤ 1000 Hemolysis
8 ++++ H > 1000
Icterus Index Icterus Appearance Scale Bilirubin (mg/dL) Representative Indices Result
1 - or + or ++ 1≤2
2 ++ 2<I≤5
3 ++ or +++ 5<I≤10
4 +++ 10<I≤15
5 +++ or ++++ 15<I≤20
6 ++++ 20<I≤40
7 ++++ 40<I≤60 Icterus
8 ++++ I>60
Lipemic Index Lipemic Appearance Scale Intralipid (mg/dL) Representative Indices Result
1 - or + L<50
2 + 50<L≤100
3 + or ++ 100<L≤200
4 ++ or +++ 200<L≤400
5 +++ or ++++ 400<L≤600
6 ++++ 600<L≤800
7 ++++ 800<L≤1000
8 ++++ L>1000 Lipemia

Intralipid® is a registered trademark of Fresenius Kabi AG, Bad Homburg, Germany

(1) Serum Index Reference Tables
Clinical and Laboratory Standards Institute (CLSI 56-A Standard) (Hemolysis, Icterus, and Lipemia/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline -Pages 23, 25, 26).